Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a combined operation targeting an subterranean weapons facility in Syria operated by the IS group, according to the British defence ministry.
The site, located using intelligence, was thought to be storing arms and explosives, the release indicated, and was situated in mountainous terrain just to the north of the historic site of Palmyra in the heart of Syria.
"Our aircraft employed laser-guided Paveway IV weapons to target a series of approach shafts leading to the depot... initial indications suggest the target was engaged successfully," the ministry announced.
There was no indication of any harm to civilians in the strike conducted Saturday night and each participating jet returned safely, the ministry further stated.
The British jets were supported by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as Daesh - enforced militant control over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This action demonstrates British leadership, and resolve to stand shoulder to shoulder with our partners, to eradicate any revival of the terrorist group and their harmful and extremist ideologies in the area," the British Defence Secretary the minister stated.
RAF aircraft have performed overwatch operations over Syria to "prevent any attempted resurgence" of the group following its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to every member of the UK armed forces participating in this mission for their skill and their courage," the Defence Secretary said. "Including them were a great many British troops stationed over the festive period. This action, to eliminate dangerous terrorists who pose a risk to our security, shows how British military are prepared to act, continuously, protecting the UK at home and powerful internationally."
In December, the United States armed forces conducted what it described as a "massive strike" on Islamic State objectives in Syria, after an assault claimed the lives of two US servicemembers and a local interpreter in the Palmyra area.
The United Nations estimates Daesh still maintains roughly 5-7 thousand combatants in both countries.